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可注射自體富含血小板纖維凝膠

可注射自體富含血小板纖維凝膠Injectable Platelet-Rich Fibrin (I-PRF)PRF於不同於PRP，在製備過程中不需加入抗凝血劑，因此PRF具備凝集功能，PRF凝集通常會發生在離心製備完成後10-20分鐘內發生凝集現象。


因此剛離心完成時，尚可經由注射方式進入體內之液體狀態PRF也被稱為Injectable-PRF。Injectable-PRF可在進入受損組織後，在受損組織凝集形成纖維凝塊，PRF纖維凝塊能夠有效將生長因子長時間留在受損部位，文獻研究中比較Injectable-PRF與 PRP 生長因子釋放的時間變化，結果發現Injectable-PRF生長因子可穩定釋放長達 10 天。而PRP 容易在早期(約製備完成後8小時以前)大量釋放出生長因子[1]。

自體富含血小板
纖維凝膠

傳統形式的自體富含血小板纖維凝膠（PRF）是在無抗凝劑的條件下，透過離心患者的血液並形成一個密集的凝膠。這個凝膠可以作為傷口敷料或應用於開放性傷口以促進愈合過程。PRF形成的纖維蛋白基質作為支架，支持細胞遷移和組織再生。在需要傷口閉合和減少疤痕的情況下特別有益，例如口腔顎面外科或皮膚科。
 

可注射自體富含血小板纖維凝膠（I-PRF）和自體富含血小板纖維凝膠（PRF）都為廣泛的醫學和美容應用提供了寶貴的治療選擇。這兩種形式的PRF利用生長因子和纖維蛋白基質的再生潛力，成為促進組織修復和再生的強大工具，各自具有獨特的優勢和應用。

臨床應用

以下是關於可注射自體富含血小板纖維凝膠（I-PRF）和自體富含血小板纖維凝膠（PRF）在各種醫學領域中的臨床應用：

可注射自體富含血小板纖維凝膠

骨科 / 復健科

頸椎/腰椎椎間盤突出或退化

肩膀、手肘及膝蓋肌腱撕裂
 

退化性關節炎

足底筋膜炎

皮膚科 / 整形外科

疤痕組織及皮膚皺紋撫平
 

協助移植的脂肪及軟骨細胞維持活性
 

婦產科

疤痕組織及皮膚皺紋撫平

​

促進子宮內膜增厚

泌尿科

間質性膀胱炎

勃起功能障礙
 

耳鼻喉科

聲帶修復
 

自體富含血小板纖維凝膠

皮膚科

燒燙傷皮膚受損
 

創傷皮膚組織受損
 

耳鼻喉科

鼓膜重建

空鼻症治療
 

顳顎關節功能改善
 

這些應用展示了I-PRF和PRF在各種醫學專業中的多功能性和潛在好處，從骨科和皮膚科到婦產科、泌尿科和耳鼻喉科。這些治療的再生特性使其在廣泛的疾病中有助於提高患者的治療效果和生活品質。

Reference List

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