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Serpera Advanced Blood
Cell Separator

TFDA Medical Device Manufacturing No. 006469

  1. Platelet recovery rate ≥ 250 x 10^3 per/µL (according to FDA CFR title 21-640.34).

  2. White blood cell retention can be adjusted according to patient needs to LR-PRP (white blood cell recovery rate ≥ 50%, retaining monocytes and lymphocytes) or LP-PRP (white blood cell recovery rate ≤ 5%).

  3. Red blood cell residual rate < 0.5%.

  4. Can be prepared as PRF for long-lasting release of highly active growth factors for up to 10 days.

  5. Different product specifications can be selected based on the injection site and range.

The Five Key Advantages of SERPERA

High platelet
recovery rate

White blood cell recovery rate

High platelet concentration

Release high-activity growth factors

Require a small blood volume and easy to use

Product Specifications

Product Description

Platelet-rich plasma (PRP) is obtained by using a patient's own blood and recovering platelets from the blood through centrifugation. Platelets are rich in various growth factors and anti-inflammatory substances, which can stimulate cell proliferation, promote blood vessel formation, reduce inflammatory responses, and assist in tissue repair (Fig. 1).

The SERPERA Advanced Blood Cell Separator employs an advanced one-step centrifugation method, creating a density gradient centrifugation based on the difference in density between the gel inside the separator and the blood cells. This effectively forms a barrier between platelets and red blood cells in whole blood, allowing for the efficient recovery of platelets while simultaneously reducing the residual red blood cell content in the platelet concentrate. The SERPERA Advanced Blood Cell Separator can be adjusted according to the treatment needs of patients, producing either pure platelet concentrate (Leukocyte-poor PRP, LP-PRP) or platelet concentrate rich in white blood cells (Leukocyte-rich PRP, LR-PRP) (Fig. 1). Additionally, it can be used to prepare platelet-rich fibrin (PRF) and platelet lysate (PL) through different preparation processes.

LP-PRP is suitable for patients in the acute inflammatory phase or those with tissues in a remodeling state, helping patients reduce inflammation and promote tissue regeneration. LR-PRP contains primarily monocytes and lymphocytes among white blood cells. In addition to supplying growth factors to the damaged area, LR-PRP can also clear scar tissue or fibrotic tissue in the damaged area through the included white blood cells, promoting tissue repair and blood vessel formation.

Product Performance

Leukocyte - rich PRP

Under the LR-PRP centrifugation parameters, a comparison was made between the concentration of blood cells in whole blood and PRP prepared using the SERPERA Advanced Blood Cell Separator. The results revealed that SERPERA was able to recover 94.44% of platelets from whole blood. The white blood cell recovery rate under LR-PRP centrifugation parameters was 46.75%. Among the white blood cells recovered in LR-PRP, monocytes and lymphocytes were the predominant types, and their concentration in LR-PRP was significantly higher compared to whole blood. Additionally, the red blood cell residual rate in PRP was <0.5% compared to whole blood. The experiment demonstrated that the use of the SERPERA Advanced Blood Cell Separator, in conjunction with LR-PRP centrifugation parameters, successfully prepared PRP rich in white blood cells.(Recovery rate calculation formula = PRP cell concentration * PRP volume / whole blood cell concentration * whole blood volume)

Leukocyte - poor PRP

Under the LP-PRP centrifugation parameters, a comparison was made between the blood cell concentration in PRP prepared using the SERPERA Advanced Blood Cell Separator and another brand of separation tube. The PRP platelet concentration prepared with SERPERA was 1132 x 10^3 per/mm^3. The experiment demonstrated that the use of the 'SERPERA Advanced Blood Cell Separator' resulted in PRP platelet concentrations that were 10 times higher than those achieved with the other brand.

Furthermore, combining the LP-PRP and LR-PRP experiments mentioned above, the white blood cell recovery rate under LP-PRP centrifugation parameters was significantly lower than the white blood cell recovery rate under LR-PRP centrifugation parameters. The SERPERA Advanced Blood Cell Separator can indeed prepare both LP-PRP and LR-PRP when combined with different centrifugation parameters.

Under the LP-PRP centrifugation parameters, a comparison was made between the concentrations of growth factors in PRP prepared using the SERPERA Advanced Blood Cell Separator and PRP prepared using another brand of separation tube. Since growth factors in PRP are primarily released from platelets, the analysis revealed that PRP prepared with SERPERA consistently exhibited higher concentrations of growth factors compared to PRP prepared with the other brand of separation tube. The experiment demonstrated that PRP prepared with the SERPERA Advanced Blood Cell Separator is rich in high-concentration growth factors, which can be advantageous in assisting tissue repair.

Product Preparation

The process of preparing PRP is as follows:

A suitable amount of blood is drawn from the patient's vein by trained healthcare personnel.

Whole blood is subjected to centrifugation using the set centrifugation parameters, leading to the separation of blood components into layers.

The blood is then injected into the "SERPERA Advanced Blood Cell Separator," and a centrifugation step is performed.

After centrifugation is complete, the upper layer of plasma, which is rich in platelets, is extracted, completing the preparation process.

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