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Platelet Lysis

Platelet Lysis (PL) is a specialized biological product derived from activated platelets. These platelets are initially stimulated to release various growth factors when exposed to specific triggers. Once this activation process is complete, PL is carefully prepared by removing all other cellular components and debris, leaving behind a concentrated solution of the released growth factors.

What sets PL apart is that the growth factors within it are in an exceptionally active state. This heightened activity makes them especially effective when introduced into damaged or injured tissues. Here's a more detailed breakdown of how PL works and its potential applications:

Activation and Growth Factors Release:
Platelets are naturally occurring blood cells known for their crucial role in blood clotting. However, they also contain a reservoir of growth factors, such as platelet-derived growth factor (PDGF), transforming growth factor-beta (TGF-β), and vascular endothelial growth factor (VEGF), among others. When platelets are activated, they release these growth factors.

Isolation of PL:
To create PL, the activated platelets are isolated from other blood components like red blood cells and white blood cells. This purification process ensures that the resulting product is rich in growth factors and devoid of other cellular elements.

Highly Activated Growth Factors:
One of the key advantages of PL is that the growth factors within it remain highly activated. This means they are primed and ready to initiate the healing and regenerative processes in damaged tissues.

Applications of PL:
PL can be used in various medical fields and applications. Its ability to reduce inflammation and stimulate cell growth makes it valuable for promoting tissue repair and regeneration. Some potential applications include wound healing, tissue regeneration in orthopedics, dermatological treatments for scars and burns, and more.

Immediate Impact:
When PL is introduced into damaged tissues, its highly activated growth factors can act quickly to reduce inflammation. They also play a crucial role in promoting the proliferation of cells necessary for tissue repair, which can accelerate the healing process.

Clinical Application

Rapid Anti-Inflammatory Action on Damaged Tissues

Treatment of Dry Eye Syndrome[1].

Reference List

  • [1] Fea, A. M., Aragno, V., Testa, V., Machetta, F., Parisi, S., D’Antico, S., Spinetta, R., Fusaro, E., Grignolo, F. M..The Effect of Autologous Platelet Lysate Eye Drops: An In Vivo Confocal Microscopy Study. BioMed Research International, 2016, 8406832.​

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