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Injectable Platelet-Rich Fibrin

Injectable Platelet-Rich Fibrin (I-PRF) is a specialized form of platelet-rich fibrin (PRF) with distinct characteristics that make it valuable in various medical and cosmetic applications. Unlike traditional PRP (Platelet-Rich Plasma), I-PRF does not require the addition of anticoagulants during its preparation. This unique feature allows I-PRF to naturally form a fibrin clot within a short period, typically within 10-20 minutes after centrifugation.

The ability of I-PRF to spontaneously form a clot makes it particularly useful for applications where a sustained release of growth factors and cytokines is desired. Once I-PRF is injected into the target area, such as injured tissues or damaged skin, it begins to clot and creates a stable, three-dimensional fibrin matrix. This matrix serves as a reservoir for various growth factors, including Platelet-Derived Growth Factor (PDGF), Transforming Growth Factor-Beta (TGF-β), and Vascular Endothelial Growth Factor (VEGF), among others.

As the fibrin matrix gradually degrades over time, it releases these growth factors in a controlled and sustained manner, providing continuous nourishment to the surrounding cells. This prolonged exposure to growth factors promotes tissue regeneration, collagen synthesis, and angiogenesis (the formation of new blood vessels). It is especially valuable in applications like orthopedics, where it can aid in the repair of tendon and ligament injuries, as well as in cosmetic procedures for skin rejuvenation and scar reduction.

Platelet-Rich Fibrin

Platelet-Rich Fibrin (PRF), in its traditional form, is prepared by centrifuging a patient's blood without anticoagulants, resulting in the formation of a dense clot. This clot can be used as a wound dressing or applied to open wounds to facilitate the healing process. The fibrin matrix formed by PRF acts as a scaffold that supports cell migration and tissue regeneration. It is particularly beneficial in cases where wound closure and scar reduction are essential, such as in oral and maxillofacial surgery or dermatology.

In summary, both Injectable Platelet-Rich Fibrin (I-PRF) and Platelet-Rich Fibrin (PRF) offer valuable therapeutic options for a wide range of medical and cosmetic applications. Their ability to harness the regenerative potential of growth factors and fibrin matrices makes them powerful tools in promoting tissue repair and rejuvenation, each with its unique advantages and applications.

Clinical Application

Certainly, here's the expanded information about the clinical applications of Injectable Platelet-Rich Fibrin (I-PRF) and Platelet-Rich Fibrin (PRF) in various medical fields:

Injectable Platelet-Rich Fibrin (I-PRF)

Orthopedics / Rehabilitation

Cervical and Lumbar Disc Herniation or Degeneration:
I-PRF can be injected into the affected areas to promote tissue repair and reduce inflammation, potentially alleviating pain and improving mobility[2].

Tendon Tears in Shoulder, Elbow, and Knee:
I-PRF injections may aid in the healing process of tendon injuries, such as rotator cuff tears or tennis elbow[3][4][5].

Degenerative Arthritis:
I-PRF may offer relief for patients with degenerative joint conditions by promoting joint health and reducing inflammation[6].

Plantar Fasciitis:
I-PRF injections can be considered for the treatment of plantar fasciitis, helping to reduce pain and promote tissue healing in the foot[7].

Dermatology / Plastic Surgery

Scar Tissue and Wrinkle Reduction:
I-PRF may be used to improve the appearance of scars and wrinkles on the skin, promoting collagen production and skin rejuvenation[8][9].

Support for Transplanted Fat and Cartilage Cells:
I-PRF can help maintain the viability of transplanted fat and cartilage cells in procedures like fat grafting and cartilage transplantation[10].

Obstetrics and Gynecology

Stress Urinary Incontinence:
I-PRF injections may be considered as a non-surgical option to address stress urinary incontinence[11].

Endometrial Thickness Enhancement:
I-PRF could potentially assist in increasing endometrial thickness, which is crucial for successful embryo implantation in fertility treatments[12].


Interstitial Cystitis:
I-PRF injections can be explored as a treatment option for interstitial cystitis, a painful bladder condition[13].

Erectile Dysfunction:
I-PRF may have applications in managing erectile dysfunction by promoting tissue repair and blood vessel health[14].

Otorhinolaryngology (Ear, Nose, and Throat)

Vocal Cord Repair:
I-PRF injections may aid in the repair of vocal cord injuries or damage, potentially improving voice function[15].

Platelet-Rich Fibrin (PRF)


Burn and Scalded Skin:
PRF can be used to treat damaged skin caused by burns or scalds, promoting healing and reducing scarring[16].

Traumatized Skin Tissues:
PRF may facilitate the repair of traumatized skin tissues, such as those from accidents or injuries[17].

Otorhinolaryngology (Ear, Nose, and Throat)

Tympanic Membrane Reconstruction:
PRF can assist in the reconstruction of the eardrum (tympanic membrane) following injury or surgery[18].

Empty Nose Syndrome Treatment:
PRF injections may be considered for treating empty nose syndrome, a condition affecting the nasal passages[19].

Improving Temporomandibular Joint Function:
PRF might be used to improve the function and health of the temporomandibular joint (jaw joint)[20].

These applications demonstrate the versatility and potential benefits of I-PRF and PRF in various medical specialties, ranging from orthopedics and dermatology to obstetrics and gynecology, urology, and otorhinolaryngology. The regenerative properties of these treatments hold promise for enhancing patient outcomes and quality of life in a wide range of conditions.

Reference List

  • [1] Miron RJ, Fujioka-Kobayashi M, Hernandez M, et al. Injectable platelet rich fibrin (i-PRF): opportunities in regenerative dentistry?. Clin Oral Investig. 2017;21(8):2619-2627.

  • [2] Cameron JA, Thielen KM. Autologous Platelet Rich Plasma for Neck and Lower Back Pain Secondary to Spinal Disc Herniation: Midterm Results. Spine Res. 2017; Vol. 3 No. 2:10

  • [3] Sengodan VC, Kurian S, Ramasamy R. Treatment of Partial Rotator Cuff Tear with Ultrasound-guided Platelet-rich Plasma. J Clin Imaging Sci. 2017;7:32.

  • [4] Halpern BC, Chaudhury S, Rodeo SA. The role of platelet-rich plasma in inducing musculoskeletal tissue healing. HSS J. 2012;8(2):137-45.

  • [5] Filardo, G., Kon, E., Della Villa, S., Vincentelli, F., Fornasari, P. M., & Marcacci, M. Use of platelet-rich plasma for the treatment of refractory jumper's knee. International orthopaedics, 2021;34(6), 909–915.

  • [6] Laudy A, B, M., Bakker E, W, P., Rekers M., Meon M, H. Efficacy of platelet-rich plasma injections in osteoarthritis of the knee: a systematic review and meta-analysis. British Journal of Sports Medicine. 2015;49:657-672.

  • [7] Monto R. R. Platelet-rich plasma efficacy versus corticosteroid injection treatment for chronic severe plantar fasciitis. Foot & ankle international, 2014;35(4), 313–318.

  • [8] Shah, S. D., Mehta, B. D., Borkar, M. A., & Aswani, R. C. Study of safety and efficacy of autologous platelet rich plasma combined with fractional CO2 laser in the treatment of post acne scars: a comparative simultaneous split-face study. International Journal of Research in Medical Sciences, 2017; 5(4), 1344–1351.

  • [9] Elnehrawy, N. Y., Ibrahim, Z. A., Eltoukhy, A. M., & Nagy, H. M. Assessment of the efficacy and safety of single platelet-rich plasma injection on different types and grades of facial wrinkles. Journal of cosmetic dermatology, 2017; 16(1), 103–111.

  • [10] Gentile, P., Di Pasquali, C., Bocchini, I., Floris, M., Eleonora, T., Fiaschetti, V., Floris, R., & Cervelli, V. Breast reconstruction with autologous fat graft mixed with platelet-rich plasma. Surgical innovation, 2013; 20(4), 370–376.

  • [11] Chiang C- and Kuo H- (2022) The Efficacy and Mid-term Durability of Urethral Sphincter Injections of Platelet-Rich Plasma in Treatment of Female Stress Urinary Incontinence. Front. Pharmacol . 2022; 13:847520.

  • [12] Chang, Y., Li, J., Chen, Y., Wei, L., Yang, X., Shi, Y., & Liang, X. Autologous platelet-rich plasma promotes endometrial growth and improves pregnancy outcome during in vitro fertilization. International journal of clinical and experimental medicine, 2015; 8(1), 1286–1290.

  • [13] Jiang, YH., Kuo, YC., Jhang, JF. et al. Repeated intravesical injections of platelet-rich plasma improve symptoms and alter urinary functional proteins in patients with refractory interstitial cystitis. Sci Rep. 2020; 10, 15218.

  • [14] Liu MC, Chang ML, Wang YC, Chen WH, Wu CC, Yeh SD. Revisiting the Regenerative Therapeutic Advances Towards Erectile Dysfunction. Cells. 2020; 9(5):1250.

  • [15] Woo SH, Kim JP, Park JJ, Chung PS, Lee SH, Jeong HS. Autologous platelet-poor plasma gel for injection laryngoplasty. Yonsei Med J. 2013; 54(6):1516-23.

  • [16] Huang, H., Sun, X., & Zhao, Y. Platelet-rich plasma for the treatment of burn wounds: A meta-analysis of randomized controlled trials. Transfusion and Apheresis Science, 2020; 102964.

  • [17] Vaheb, M., Karrabi, M., Khajeh, M., Asadi, A., Shahrestanaki, E., & Sahebkar, M. Evaluation of the Effect of Platelet-Rich Fibrin on Wound Healing at Split-Thickness Skin Graft Donor Sites: A Randomized, Placebo-Controlled, Triple-Blind Study. The international journal of lower extremity wounds, 2021; 20(1), 29–36.

  • [18] Shukla A, Kaurav YS, Vatsyayan R. Novel Use of Platelet Rich Fibrin Membrane in Transcanal Myringoplasty: A Prospective Study. Indian J Otolaryngol Head Neck Surg. 2020; 72(3):355-362.

  • [19] Chang C. F. Using platelet-rich fibrin scaffolds with diced cartilage graft in the treatment of empty nose syndrome. Ear, nose, & throat journal, 2021; 1455613211045567.

  • [20] Giacomello, M., Giacomello, A., Mortellaro, C., Gallesio, G., & Mozzati, M. Temporomandibular joint disorders treated with articular injection: the effectiveness of plasma rich in growth factors-Endoret. The Journal of craniofacial surgery, 2015; 26(3), 709–713.

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